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Journal Articles and Book Chapters

2006

 

Jan L. Brandes.MD; David Kudrow, MD; Stuart R. Stark, MD; C. Phillip O’Carroll, MD; James U.Adelman, MD; Francis J. O’Donnell, DO; W. James Alexander,MD, MPH; Susan Spruill, MS; Pamela S. Barrett,, PharmD; Shelly E. Lener, PharmD. Sumatriptan / Naproxen Sodium for the Acute Treatment of Migraine: Superior Efficacy Compared with Monotherapy and Placebo. JAMA (in review, June 2006)

 

20065

William P. Petros, Penelope J. Hopkins, Susan Spruill, Gloria Broadwater, James J. Vredenburgh, O. Michael Colvin, William P.Peters, Roy B. Jones, Jeff Hall, and Jeffrey Marks, 2005. Associations Between Drug Metabolism Genotypes, Chemotherapy Pharmacokinetics and Overall Survival in Patients With Breast Cancer. J. Clininical Oncology. 23(25):6117-6125.

 

2005

Timothy R. Smith, MD, Abraham Sunshine, MD, Stuart R. Stark, MD, Diane E. Littlefield, RN, MSN, Susan E. Spruill, MS, and W. James Alexander, MD, MPH. 2005. Sumatriptan and Naproxen Sodium for Acute Treatment of Migraine. Headache.45:8(September):983-991.

 

2002

Susan E. Spruill, Jun Lu, Sarah Hardy and Bruce Weir. 2002. Assessing Sources of Variability in Microarray Gene Expression Data. BioTechniques. 33(4):916-923.

 

2001

Kenneth C. Mills, Susan E. Spruill, Roy W. Kanne, Katherine M. Parkman, and Ying Zhang, 2001. Tunnel Vision, Stimulants, Sedatives and Fatigue: Risk Factors for Driving and Piloting, Human Factors. 43(2):310-327.

 

2000

Lu, J., S. Hardy, W. Tao, S. Muse, B. Weir, and S. Spruill. 2001. Classical Statistical Approaches to Molecular Classification of Cancer From Gene Expression Profiling.  Proceedings from the 1st Annual Critical Assessment of Microarray Data Analysis Conference (CAMDA’00). Duke University, Durham, NC. December 18-19, 2000.

 

1996

Colven, Christine E., Spruill, Susan E., Bullard, Mary Jo and Earnest Lori R. 1996. From Start to Finish in Record Time.  Applied Clinical Trials 5(4), 64-67.

 

1996

Spruill, Susan E., Wilder, Lisa A. and Colven, Christine E. 1996. Selecting a CRO to Speed the Product to Market. Scrip Magazine, July/August Issue 48, 18-19.

 

1996

K.C. Mills, K.M. Parkman and S.E. Spruill, 1996. A PC-Based Software Test for Measuring Alcohol and Drug Effects in Human Subjects, Alcohol Clinic. Exp. Res., VOL 20:9,pp 1582-1591.

 

1993

Shafer, S.R., R.A. Reinert, G. Eason, and S.E. Spruill. 1993.  Analysis of ozone concentration - biomass response relationships among open-pollinated families of loblolly pine. Can. J. For. Res. 23:706-715.

 

1993

Spruill, S.E., D. Richter, M.L. Gumpertz, J.O. Rawlings, and H.L Allen. 1993. Use of edaphic variables to control experimental error: A case study on blocking and use of covariance. Soil Science 156(3):156-162.

 

1993

Rawlings, John O. and Susan E. Spruill. 1993. Combined analysis of multi-experimental data to estimate polynomial and nonlinear mixed model regressions. In Case Studies in Biometry. Wiley and Sons.

 

1992

Rawlings, J., and S. Spruill. 1992. Response model synthesis of the Southern Commer­cial Forest Re­search Data. Presented at the Air and Waste Management Conference on Tropospheric Ozone and the Environment II: Effects, Modeling and Control and the Response of Southern Commercial Forest to Air Pollution. Atlanta, GA. Nov 4-7, 1991. Transaction No. 21.

 

1991

Heagle, Allen S., Michael R. McLaughlin, Joseph E. Miller, Ronald L. Joyner, and Susan E. Spruill. 1991. Adaptation of white clover population to chronic ozone stress. New Phytol. 119:61-68.

 

1991

Flagler, R., S. Spruill, A. Chappelka, T. Dean, L. Kress, and J. Reardon. 1992. Growth of three South­ern pine species as affected by acid rain and ozone. Presented at the Air and Waste Management Conference on Tropospheric Ozone and the Environment II: Effects, Modeling and Control and the Response of Southern Commercial Forest to Air Pollution. Atlanta, GA. Nov 4-7, 1991. Transaction No. 21.

 

1990

Lesser, V.M., J.O. Rawlings, S.E. Spruill, and M.C. Somerville. 1990. Effects of ozone on agricul­tural crops: statisti­cal meth­odolo­gies and dose-re­sponse rela­tion­ships. Crop Science. 30:148-155.

 

1989

Somerville, M.C., S.E. Spruill, J.O. Rawlings, and V.M. Lesser. 1989. Impact of ozone and sulfur dioxide on yield of agricultural crops. NCARS Technical Bulletin 292, North Carolina State University, Raleigh, North Carolina.

 

1988

Spruill, S.E., V.M. Lesser, M.C. Somerville, and J.O. Rawlings. 1988. Methods used for manag­ing and analyz­ing the data stored in the NCLAN Data Library. Environmental Pollution - Special Issue: Response of Crops to Air Pollutants 53(1-4):462-465.

 

1985

Spruill, S.E. and E.J. Eisen. 1985. Ovulation rate and embryo survival during gestation and the effects of ovariectomy on maternal nurturing ability. J. Anim. Sci., 61(4):834-843.

 

1984

Spruill, S.E. and E.J. Eisen. 1984. Correlated response in fetal mortality during three phases of gestation in mice selected for large litters. J. Anim. Sci., Abstr.

 

1984

Spruill, S.E. 1984. Correlated responses in female reproductive traits in mice selected for increased litter size. Masters Thesis. North Carolina State University.

 

Presentations

 

2006

Brandes, Jan L.; Kudrow, David; Stark, Stuart; O’Carroll, C. Phillip; Adelman, James U.; O’Donnell, Frank; Spruill Susan; Alexander, W. James; Barrett, Pamela; Lener, Shelly. Superior Efficacy of Combination Therapy over Monotherapy: Results of a Fixed Single-tablet Formulation of Sumatriptan Rt Techonology and Naproxen Sodium in the Acute Treatment of Migraine in the Traditional Treatment Paradigm.  Platform Presentation at the 48th Annual Scientific Meeting of the American Headache Society. (June 2006)

 

2005

J.R. Plachetka, S.E. Spruill, and W.J. Alexander. Baseline Nausea Status Influences Response to MT 100, But Not Naproxen or Sumatriptan: Meta-Analysis Results From the MT 100 Development Program.  Poster Presentation at the 47th Annual Scientific Meeting of the American Headache Society. (June 2005)

 

2005

J.R. Plachetka, S.E. Spruill, and W.J. Alexander. Patients Without Baseline Nausea Respond Best to MT 100 for Pain Relief: Evidence For a Role of Dopamine in Migraine? Poster Presentation at the 47th Annual Scientific Meeting of the American Headache Society. (June 2005)

 

 

William Wargin, B.S. Pharm, Ph.D., Diane Littlefield, RN, MSN, Susan Spruill, MS, John R. Plachetka, Pharm.D. The pharmacokinetic profile of dihydroergotamine from MT 300 vs. DHE 45.Poster Presentations at the 2003 American College of Clinical Pharmacy Scientific Meeting (November 2003)

 

 

Donna Gilbert, Ph.D., Susan Spruill, MS, William Wargin, Ph.D., Diane Littlefield, RN, MSN, and John R. Plachetka, Pharm.D.  Over-encapsulated Imitrex 50 mg tablets are bioequivalent to marketed Imitrex 50 mg tablets Poster Presentations at the 2003 American College of Clinical Pharmacy Scientific Meeting (November 2003)

 

 

Susan  E. Spruill, M.S., Bill A. Wargin, Ph.D., Diane E. Littlefield, M.S.N., Leslie A. Davidson, Pharm.D., John R. Plachetka, Pharm.D.  The Pharmacokinetics and Bioavailability of Metoclopramide and Naproxen from MT 100 Tablets Poster Presentations at the 2003 American College of Clinical Pharmacy Scientific Meeting (November 2003)

 

 

Egilius Spierings, MD, Diane Littlefield, RN, MSN, Julie Borland, B.Pharm., Susan Spruill, MS, John Plachetka, Pharm. D.  Tolerability profile of  MT 100 during one year of treatment. Poster Presentations at the XI Congress of the International Headache Society (September 2003)

 

 

Timothy Smith, MD, Diane Littlefield, RN, MSN, Jeannie Allen, BSN, Susan Spruill, MS, John Plachetka, Pharm. D. MT 300 is an effective, well tolerated injectable antimigraine therapy. Poster Presentations at the XI Congress of the International Headache Society (September 2003)

 

 

Richard Pellegrino, MD, Diane Littlefield, RN, MSN, Julie Borland, B.Pharm, Susan Spruill, MS, John Plachetka, Pharm. D. Comparative efficacy of MT 100 and sumatriptan 50 mg in treating acute migraine subjects with severe pain or nausea at baseline.  Poster Presentations at the XI Congress of the International Headache Society (September 2003)

 

 

Ninan Mathew, MD, Susan E. Spruill, MS, Diane E. Littlefield, RN, MSN, Alison C. Lyke, PharmD, John R. Plachetka, PharmD   Time course of symptom relief with various anti-migraine therapies.   Poster Presentations at the XI Congress of the International Headache Society (September 2003)

 

 

Egilius L.H. Spierings, PhD, Susan E. Spruill, MS, Gemma Matthys, CCRA, Diane Littlefield, RN, MSN, and John R. Plachetka, PharmD  Defining and analyzing meaningful relief in clinical trials of acute migraine headache.  Poster Presentations at the 2003 AHS 45th Annual Scientific Meeting   (June 2003)

 

 

Benjamin M. Frishberg, M.D., Diane Littlefield, RN, MSN, Jeannie Allen, BSN, Susan Spruill, MS, and John Plachetka, Pharm. D. A new formulation of DHE is effective for sustaining relief in acute treatment of migraine.  Poster Presentations at the 2003 AHS 45th Annual Scientific Meeting   (June 2003)

 

2001

Quinn, A.M. Guida, M., Shen, J. and Spruill, S. Predicting Regulatory Elements for Functional SNP Discovery. (2001) TIGR 5th Annual Conference on Computational Genomics Program and Abstracts, pg 5.

 

2001

Petros, W., Hopkins, P., Vredenburgh, J., Spruill, S., Broadwater, G., Colvin, M., Marks, J. and Hall, J. Associations Between Variants in Several Drug Metabolism Genes and Chemotherapy Pharmacokinetics or Clinical Response. 2001.  Presented at the 92nd Annual AACR Meeting.  New Orleans, LA. March 24-28, 2001.

 

2001

S. Spruill, J. Lu, S. Hardy, M. Guida, B. Weir, S. Muse and J. Baker. Analysis of Microarray Data:  A Proof of Concept. 2001 Presented at the 2001 Spring Meeting for International Biometrics Society Eastern North American Region. The Impact of Technology on Biometrics. Charlotte, NC. March 25-28, 2001.

 

2000

Lu, J., S. Hardy, W. Tao, S. Muse, B. Weir, and S. Spruill. 2000. Classical Statistical Approaches to Molecular Classification of  Cancer From Gene Expression Profiling.  Presented at the 1st Annual Critical Assessment of Techniques for Microarray Data Analysis Conference (CAMDA’00). Duke University, Durham, NC. December 18-19, 2000.

 

1996

Atkinson, S., S. Spruill, S.E., Wakeford, C.W. 1996. Qualification Stage for Enrichment Trials. Presented at the 9th Annual DIA Meeting on Statistical Issues in the Pharmaceutical Industry. Hilton Head, SC March 31-April 2, 1996.

 

1991

Spruill, S.E., and J.O. Rawlings. 1991. Effects of ozone and acid rain in southern pines after two years of expo­sure and comparison to earlier results. Presented at the Annual Meeting of the Southern Commercial Forest Research Cooperative. Clemson, SC. May 13-15, 1991.

 

1991

Mickler, Robert, and Susan Spruill. 1991. An overview of guidelines cooperating agencies should follow to insure data quality. Presented at the 1st Annual Meeting of the Southern Global Change Program. Otto, NC. May 21-23, 1991.

 

1991

Rawlings, J. and S. Spruill. 1991. Response model synthesis of the Southern Commercial Forest Research Data. Presented at the Air and Waste Management Conference on Tropospheric Ozone and the Environment II: Effects, Modeling and Control and the Response of Southern Commercial Forest to Air Pollution. Atlanta, GA. Nov 4-7, 1991.

 

1991

Flagler, R., S. Spruill, A. Chappelka, T. Dean, L. Kress and J. Reardon. 1991. Growth of three Southern pine species as affected by acid rain and ozone. Presented at the Air and Waste Management Conference on Tropospheric Ozone and the Environment II: Effects, Modeling and Control and the Response of Southern Commercial Forest to Air Pollution. Atlanta, GA. Nov 4-7, 1991.

 

1990

Flagler, R.B., and S.E. Spruill. 1990. Regional response of southern pines to acid rain and ozone. 11th North American Forest Biology Workshop. Athens, GA, June 1990.

 

1990

Spruill, Susan E. 1990. Analysis of the SCFRC intensive field experiments. Presented at the Annual Meet­ing of the Southern Commercial Forest Research Cooperative. Auburn, AL. August 20-22, 1990.

 

 

Technical Reports

 

1992

Spruill, Susan E., and John O. Rawlings. 1992. Four ways to create Gabriel's Biplots for graphic representation of principal component analyses. North Carolina State University Institute of Statistics Mimeograph Series No. 2213.

 

1992

Lieberman, Elliot, John Schakenbach, Doris A. Price, William Warren-Hicks, Susan E. Spruill, and Jane E. Mudano. 1992.  Extended Relative Accuracy Test Audits of SO2 and NOx Continuous Emissions Monitoring System at a Coal-Fired Power Plant.

 

1992

Lieberman, Elliot, John Schakenbach, Doris A. Price, William Warren-Hicks, Susan E. Spruill, and Jane E. Mudano. 1992.   Assessment of Statistical Tests in 40 CFR 75.21 (FR, 12/3/91): Alternative Monitoring Systems.

 

1992

Spruill, Susan E.  Using Unbiased Estimates of Variance and Standard Errors in the Precision and Bias Tests for Alternative Monitoring Systems.  Prepared for Elliot Lieberman of Emissions Monitoring Division of the Acid Rain Division (July 15, 1992).

 

1989

Shafer S., S. Spruill, and M. Somerville. 1989. Response of loblolly pine seedlings to ozone and simulated acidic rain in controlled exposures: Results of studies conducted by the Southern Commercial Forest Research Cooperative, 1986-1987. A Report to USFS/USDA.

 

1986

Eisen, E.J. and S.E. Spruill. 1986. Selection for large litter size can improve all of its components. 1986 Report of Department of Animal Science, North Carolina State University.

 

1986

Lesser, V.M., J.O. Rawlings, S.E. Spruill, and M.K. Nations. 1986. Data Synthesis and Analysis Program (SERCLAP). In: National Crop Loss Assessment Network (NCLAN) 1985 Annual Report, W.W. Heck, et.al, pp. 193-222. Environmental Research Laboratory, Office of Research and Development, Corvallis, Oregon 97333 (EPA/600/3-87/031).

 

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